Primary adrenal failure is referred to as Addison’s disease or adrenocortical insufficiency.
This condition occurs when the adrenals are damaged or in limited functioning. They normally produce enough of the stress-releasing hormones, cortisol, in response to adrenalin, adrenaline. When the adrenals are under-functioning, the brain senses a need for more and so releases more of these chemicals. This is not always a problem, as excess cortisol can help keep the body healthy. However, when Addison’s is present, it is usually because the adrenals are overactive. There is often a decreased level of adrenalin, which can cause pain and weakness, difficulty with digestion, depression and weight loss.
Addison’s disease can occur at any stage of life, but it tends to appear before the age of 30. The exact cause is unknown. It can occur in adults or children. Other possible causes include cancer, diabetes, excessive thyroid hormones and some medications. In some cases, it can be caused by the autoimmune system attacking the adrenals, which is called primary adrenal toxicity.
The symptoms of Addison’s Disease include weight loss, depression, fever, hot flashes, muscle weakness and fatigue. The most common treatment for Addison is corticosteroids. They are used for short term relief, but the side effects can be serious. They also have many undesirable interactions with other drugs.
Other forms of Addison’s Disease include juvenile hyperinsulinemia and the Addisonian syndrome. Juvenile hyperinsulinemia occurs when an overproduction of insulin occurs in the body. People who have juvenile hyperinsulinemia usually have higher than normal levels of glucose and high cholesterol levels. People who suffer from Addison’s Disease generally have these two conditions.
Addisonian Syndrome occurs when a person has a low level of insulin sensitivity, but the body still produces adequate amounts of the hormone in order to provide energy. The condition is associated with Addison’s Disease. The symptoms of Addison are the same as those for Addison’s Disease, but include fatigue, low energy, nausea and depression. However, in Addison Syndrome the skin and joints are very dry and cracked.
If Addison is left untreated, it can lead to Addisons Disease. This is a dangerous condition that occurs when there is too much cortisol in the body.
It can result in organ failure or organ necrosis. It can cause kidney damage and death. There are ways to prevent Addisons Disease from progressing to Addisons Disease.
There are treatments available for Addisons Disease. Corticosteroids are one such treatment. These medications can help to regulate the production of cortisol and also improve the function of the pancreas. Corticosteroids can help reduce pain and improve the function of the liver, and in many cases, they can increase the immune system. Corticosteroid therapy should only be started after trying all other therapies.
Some doctors recommend surgery, and others do not. If you think you may have Addisons Disease, talk with your doctor about a course of treatment.
Corticosteroids are usually administered by injection into the armpit area. They work by blocking the receptors on the adrenal glands in your body. This blocks the production of cortisol which in turn helps to regulate your body’s normal function. Corticosteroids should not be used long-term, as they have a negative effect on the liver.
Long-term use of corticosteroids can cause nausea and vomiting and weight gain. You may also experience weakness, loss of appetite and nausea. If you are taking any form of oral contraceptives or a blood pressure medication, you should stop taking them before beginning any therapy. for Addison’s Disease. If you have a family history of this disease, you should be tested for cancer and heart disease as well.
If Addison’s disease is left untreated, it may progress into Addison’s Disease Dementia. This is a more serious condition that occurs when there is a decrease in the amount of dopamine in the brain, which can be caused by Addison’s Disease itself. As Addison’s Disease progresses, dopamine levels begin to decrease. Patients suffering from Addison’s Disease Dementia may start to show signs of depression, memory loss, thinking problems, speech problems, personality changes and confusion. Medications are sometimes prescribed to control these symptoms.
Treatment for Addison’s Disease is dependent on the cause of the disease. Corticosteroids are the most common option.